Jose Mourinho’s side will go to the Vitality Stadium with the aim of claiming all three points, with Tottenham and Liverpool hot on their tails in the fight for second place.
However, with an FA Cup semi final match against Tottenham on Saturday, Mourinho could make some changes in order to rest some his stars for that clash at Wembley.
Here is how Manchester United could line up on Wednesday:
There could be some changes at the back for United with Saturdays’s FA Cup semi final kept in mind.
Eric Bailly missed out on Sunday, with Mourinho confirming that the reason for the centre back’s absence was partially down to tactical reasons, but also because of their hectic schedule over the next week. Therefore, we could see Victor Lindelof keep his place in the back four, with Bailly rested for the weekend.
Mourinho may also opt to rest right back Antonio Valencia, which could see Ashley Young take his place on the right of midfield, and out of favour Luke Shaw given a rare start for the Red Devils.
Mourinho is unlikely to make too many changes, so Nemanja Matic, Ander Herrera and Paul Pogba are all expected to keep their usual places in the starting lineup.
Jesse Lingard could be brought in for Juan Mata, after the Spanish midfielder played the 90 minutes on Sunday.
Lingard could play in a three with Sanchez and Pogba, with Matic and Herrera playing a deeper midfield role. Or Mourinho may opt to play Pogba further back, in a 4-3-2-1 formation.
Romelu Lukaku is expected to start up front for United. He is likely to lead the line, with the support of Sanchez, Lingard and Pogba behind him.
Lukaku has netted 15 times in the Premier League this term, and will be looking to add to that tally when United make the trip to Bournemouth on Wednesday evening.